Patient Support

Complete
commitment
to your
patients

LEARN MORE

DOSING

Two dosing
options
for flexibility

LEARN MORE

SAFETY

Safety
demonstrated
in adults with
previously
treated MCL

LEARN MORE

EFFICACY

Powerful
results
sustained
across trials

LEARN MORE

THE BRUKINSA DIFFERENCE

Designed to
shut off BTK

LEARN MORE

24-hour inhibition of BTK was maintained at 100% in PBMCs and 94% to 100%
in lymph nodes when taken at the recommended total daily dose of 320 mg.
The clinical significance of 100% inhibition has not been established.1,2

BTK=Bruton’s tyrosine kinase; PBMCs=peripheral blood mononuclear cells.

INDICATION

BRUKINSA® (zanubrutinib) is a kinase inhibitor indicated for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.

This indication is approved under accelerated approval based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

IMPORTANT SAFETY INFORMATION

WARNINGS AND PRECAUTIONS

Hemorrhage

Fatal and serious hemorrhagic events have occurred in patients with hematological malignancies treated with BRUKINSA monotherapy. Grade 3 or higher bleeding events including intracranial and gastrointestinal hemorrhage, hematuria and hemothorax have been reported in 2% of patients treated with BRUKINSA monotherapy. Bleeding events of any grade, including purpura and petechiae, occurred in 50% of patients treated with BRUKINSA monotherapy.

Bleeding events have occurred in patients with and without concomitant antiplatelet or anticoagulation therapy. Co-administration of BRUKINSA with antiplatelet or anticoagulant medications may further increase the risk of hemorrhage.

Monitor for signs and symptoms of bleeding. Discontinue BRUKINSA if intracranial hemorrhage of any grade occurs. Consider the benefit-risk of withholding BRUKINSA for 3-7 days pre- and post-surgery depending upon the type of surgery and the risk of bleeding.

THE BTK INHIBITOR DEMONSTRATED TO PROVIDE COMPLETE AND SUSTAINED INHIBITION1,2
The Brukinsa Difference
Efficacy
Safety
Dosing
Patient Support